Ernährung Frühgeborener und ihr Einfluss auf die Körperzusammensetzung

Die Ernährung eines unreifen Frühgeborenen stellt im neonatologischen Alltag eine besondere Herausforderung dar. Während sich bisher Studien zur Beurteilung des Wachstums von Frühgeborenen hauptsächlich auf anthropometrische Parameter oder den BMI konzentrierten, wird die Messung der Körperzusammensetzung ein immer wichtigeres Instrument, um eine detaillierte Beurteilung des Gesundheitszustands und der Auswirkungen von Ernährungsinterventionen zu erhalten.

Schlüsselwörter

Ernährung - Frühgeborene - Körperzusammensetzung - neurokognitives Outcome - metabolische Gesundheit

Keywords

Nutrition - premature infants - body composition - neurocognitive outcome - metabolic health

• Literatur

• 1 Stocker JT, Dehner LP, Husain AN. Means and standard deviations of weights and measurements of lifeborn infants by body weight (Appendix 28-29). 2nd ed. In: Stocker JT, Dehner LP (eds.) Stocker & Dehner’s Pediatric Pathology. Philadelphia: Lippinkott Williams & Wilkins; 2002: 1302-1304
• 2 Riskin A, Picaud JC, Shamir R. et al. ESPGHAN/ESPEN/ESPR/CSPEN guidelines on pediatric parenteral nutrition: Standard versus individualized parenteral nutrition. Clin Nutr 2018; 37: 2409-2417
• 3 Embleton ND, Jennifer Moltu S, Lapillonne A. et al. Enteral Nutrition in Preterm Infants (2022): A Position Paper From the ESPGHAN Committee on Nutrition and Invited Experts. J Pediatr Gastroenterol Nutr 2023; 76: 248-268
• 4 Agostoni C, Buonocore G, Carnielli VP. et al. Enteral nutrient supply for preterm infants: commentary from the European Society of Paediatric Gastroenterology, Hepatology and Nutrition Committee on Nutrition. J Pediatr Gastroenterol Nutr 2010; 50: 85-91
• 5 Johnson MJ, Wootton SA, Leaf AA. et al. Preterm birth and body composition at term equivalent age: a systematic review and meta-analysis. Pediatrics 2012; 130: e640-e649
• 6 Cerasani J, Ceroni F, De Cosmi V. et al. Human Milk Feeding and Preterm Infants’ Growth and Body Composition: A Literature Review. Nutrients 2020; 12
• 7 Strommen K, Blakstad EW, Moltu SJ. et al. Enhanced nutrient supply to very low birth weight infants is associated with improved white matter maturation and head growth. Neonatology 2015; 107: 68-75
• 8 Strydom K, Van Niekerk E, Dhansay MA. Factors affecting body composition in preterm infants: Assessment techniques and nutritional interventions. Pediatr Neonatol 2019; 60: 121-128
• 9 Fomon SJ, Haschke F, Ziegler EE. et al. Body composition of reference children from birth to age 10 years. Am J Clin Nutr 1982; 35: 1169-1175
• 10 Hamatschek C, Yousuf EI, Mollers LS. et al. Fat and Fat-Free Mass of Preterm and Term Infants from Birth to Six Months: A Review of Current Evidence. Nutrients 2020; 12
• 11 Ellis KJ. Human body composition: in vivo methods. Physiol Rev 2000; 80: 649-680
• 12 Kouwenhoven SMP, Antl N, Twisk JWR. et al. Methods to Assess Fat Mass in Infants and Young Children: A Comparative Study Using Skinfold Thickness and Air-Displacement Plethysmography. Basel: Life 2021; 11
• 13 Schutz Y, Kyle UU, Pichard C. Fat-free mass index and fat mass index percentiles in Caucasians aged 18-98 y. Int J Obes Relat Metab Disord 2002; 26: 953-960
• 14 Wells JC. Toward body composition reference data for infants, children, and adolescents. Adv Nutr 2014; 5: 320S-329S
• 15 Giannì ML, Roggero P, Morlacchi L. et al. Formula-fed infants have significantly higher fat-free mass content in their bodies than breastfed babies. Acta Paediatr 2014; 103: e277-e281
• 16 Wiechers C, Kirchhof S, Maas C. et al. Neonatal body composition by air displacement plethysmography in healthy term singletons: a systematic review. BMC Pediatr 2019; 19: 489
• 17 Wells JC, Williams JE, Chomtho S. et al. Body-composition reference data for simple and reference techniques and a 4-component model: a new UK reference child. Am J Clin Nutr 2012; 96: 1316-1326
• 18 Dewey KG. Growth characteristics of breast-fed compared to formula-fed infants. Biol Neonate 1998; 74: 94-105
• 19 Dewey KG, Peerson JM, Brown KH. et al. Growth of breastfed infants deviates from current reference data: a pooled analysis of US, Canadian, and European data sets. World Health Organization Working Group on Infant Growth. Pediatrics 1995; 96: 495-503
• 20 Gianni ML, Roggero P, Orsi A. et al. Body composition changes in the first 6 months of life according to method of feeding. J Hum Lact 2014; 30: 148-155
• 21 Chomtho S, Wells JC, Davies PS. et al. Early growth and body composition in infancy. Adv Exp Med Biol 2009; 646: 165-168
• 22 Gale C, Logan KM, Santhakumaran S. et al. Effect of breastfeeding compared with formula feeding on infant body composition: a systematic review and meta-analysis. Am J Clin Nutr 2012; 95: 656-669
• 23 Ramel SE, Zhang L, Misra S. et al. Do anthropometric measures accurately reflect body composition in preterm infants?. Pediatr Obes 2017; 12: 72-77
• 24 Wiechers C, Avellina V, Luger B. et al. Body Composition of Preterm Infants following Rapid Transition to Enteral Feeding. Neonatology 2022; 119: 246-254
• 25 Manapurath R, Gadapani B, Pereira-da-Silva L. Body Composition of Infants Born with Intrauterine Growth Restriction: A Systematic Review and Meta-Analysis. Nutrients 2022; 14
• 26 Forsum EK, Flinke E, Olhager E. et al. Premature birth was not associated with increased body fatness in four-year-old boys and girls. Acta Paediatr 2020; 109: 327-331
• 27 Alja’nini Z, Merlino-Barr S, Brumfiel A. et al. Effect of parenteral nutrition duration on patterns of growth and body composition in very low-birth-weight premature infants. JPEN J Parenter Enteral Nutr 2021;
• 28 Wiechers C, Kirchhof S, Balles L. et al. Neonatal body composition: crossectional study in healthy term singletons in Germany. BMC Pediatr 2019; 19: 488
• 29 McLeod G, Sherriff J, Hartmann PE. Comparing different methods of human breast milk fortification using measured v. assumed macronutrient composition to target reference growth: a randomised controlled trial. Br J Nutr 2016; 115: 431-439
• 30 Unger S, Stintzi A, Shah P. et al. Gut microbiota of the verylow-birth-weight infant. Pediatr Res 2015; 77: 205-213
• 31 Salas AA, Travers CP, Jerome ML. et al. Percent Body Fat Content Measured by Plethysmography in Infants Randomized to High- or Usual-Volume Feeding after Very Preterm Birth. J Pediatr 2021; 230: 251-254 e253
• 32 Best KP, Sullivan TR, Gunaratne AW. et al. Effect of Docosahexaenoic Acid (DHA) Supplementation of Preterm Infants on Growth, Body Composition, and Blood Pressure at 7-Years Corrected Age: Follow-Up of a Randomized Controlled Trial. Nutrients 2023; 15
• 33 Shunova A, Bockmann KA, Minarski M. et al. Choline Content of Term and Preterm Infant Formulae Compared to Expressed Breast Milk-How Do We Justify the Discrepancies?. Nutrients 2020; 12
• 34 Bockmann KA, von Stumpff A, Bernhard W. et al. Fatty acid composition of adipose tissue at term indicates deficiency of arachidonic and docosahexaenoic acid and excessive linoleic acid supply in preterm infants. Eur J Nutr 2021; 60: 861-872
• 35 Pfister KM, Zhang L, Miller NC. et al. Early body composition changes are associated with neurodevelopmental and metabolic outcomes at 4 years of age in very preterm infants. Pediatr Res 2018; 84: 713-718
• 36 Ramel SE, Gray HL, Christiansen E. et al. Greater Early Gains in Fat-Free Mass, but Not Fat Mass, Are Associated with Improved Neurodevelopment at 1 Year Corrected Age for Prematurity in Very Low Birth Weight Preterm Infants. J Pediatr 2016; 173: 108-115
• 37 Ramel SE, Haapala J, Super J. et al. Nutrition, Illness and Body Composition in Very Low Birth Weight Preterm Infants: Implications for Nutritional Management and Neurocognitive Outcomes. Nutrients 2020; 12
• 38 Bell KA, Matthews LG, Cherkerzian S. et al. Associations of Growth and Body Composition with Brain Size in Preterm Infants. J Pediatr 2019; 214: 20-26 e22
• 39 de Fluiter KS, van Beijsterveldt IALP, Breij LM. et al. Association Between Fat Mass in Early Life and Later Fat Mass Trajectories. JAMA Pediatrics 2020; 174: 1141-1148
• 40 Fewtrell MS, Lucas A, Cole TJ. et al. Prematurity and reduced body fatness at 8-12 y of age. Am J Clin Nutr 2004; 80: 436-440
• 41 Gianni ML, Roggero P, Piemontese P. et al. Boys who are born preterm show a relative lack of fat-free mass at 5 years of age compared to their peers. Acta Paediatr 2015; 104: e119-e123
• 42 Bortolotto CC, Santos IS, Dos Santos Vaz J. et al. Prematurity and body composition at 6, 18, and 30 years of age: Pelotas (Brazil) 2004, 1993, and 1982 birth cohorts. BMC Public Health 2021; 21: 321
• 43 Belfort MB, Martin CR, Smith VC. et al. Infant weight gain and school-age blood pressure and cognition in former preterm infants. Pediatrics 2010; 125: e1419-e1426
• 44 Lapillonne A, Griffin IJ. Feeding preterm infants today for later metabolic and cardiovascular outcomes. J Pediatr 2013; 162: S7-S16
• 45 Barker DJ. The origins of the developmental origins theory. J Intern Med 2007; 261: 412-417
• 46 Barker DJ, Osmond C, Forsen TJ. et al. Trajectories of growth among children who have coronary events as adults. N Engl J Med 2005; 353: 1802-1809
• 47 Barker DJ, Gluckman PD, Godfrey KM. et al. Fetal nutrition and cardiovascular disease in adult life. Lancet 1993; 341: 938-941
• 48 Heindel JJ, Skalla LA, Joubert BR. et al. Review of developmental origins of health and disease publications in environmental epidemiology. Reprod Toxicol 2017; 68: 34-48
• 49 O’Shea TM, Jensen ET, Yi JX. et al. Association of Growth During Infancy with Neurodevelopment and Obesity in Children Born Very Preterm: The Environmental Influences on Child Health Outcomes Cohort. J Pediatr 2024; 271
• 50 Bell KA, Ramel SE, Robinson DT. et al. Body composition measurement for the preterm neonate: using a clinical utility framework to translate research tools into clinical care. J Perinatol 2022; 42: 1550-1555