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Synthesis
DOI: 10.1055/a-2685-2029
Short Review

Design, Synthesis, and Self-Organization of Nature- and Bio-Inspired Homochiral Helical Complex Systems

Virgil Percec
1   Chemistry, University of Pennsylvania, Philadelphia, United States (Ringgold ID: RIN6572)
,
Jasper Adamson
1   Chemistry, University of Pennsylvania, Philadelphia, United States (Ringgold ID: RIN6572)
2   School of Engineering, Tallinn University of Technology, Tallinn, Estonia (Ringgold ID: RIN54561)
,
Dipankar Sahoo
1   Chemistry, University of Pennsylvania, Philadelphia, United States (Ringgold ID: RIN6572)
,
Devendra S. Maurya 
1   Chemistry, University of Pennsylvania, Philadelphia, United States (Ringgold ID: RIN6572)
› Author Affiliations
Supported by: National Science Foundation DMR-2104554 and DMR-1720530
Supported by: European Union Agency for Cybersecurity Grant no. 2021-2027.6.01.23-0034
Supported by: Alexander von Humboldt Foundation, Germany
Supported by: P. Roy Vagelos chair at the University of Pennsylvania
› Further Information
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Helical homochirality is available in Nature, Biology and, most recently, also in synthetic systems. Selected examples of helical complex systems from Nature, Biology and synthetic chemistry will be briefly discussed, most probably for the first time, in a single publication. When available, the mechanisms of the origin of their homochirality will be presented. In order to encourage new discoveries, the historical events of many discoveries will also be highlighted. Potential connections between the homochirality in nature and biology as well as in nature- and bio-inspired macroscopic, molecular and supramolecular complex systems will be mentioned.



Publication History

Received: 05 July 2025

Accepted after revision: 18 August 2025

Accepted Manuscript online:
18 August 2025

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