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Synthesis
DOI: 10.1055/a-2685-2029
DOI: 10.1055/a-2685-2029
Short Review
Part of the Special Topic Romanian Chemists in Synthesis
Design, Synthesis, and Self-Organization of Nature- and Bio-Inspired Homochiral Helical Complex Systems
Authors
Financial support by the National Science Foundation, United States (Grants No. DMR-2104554 and DMR-1720530), the P. Roy Vagelos chair at the University of Pennsylvania, United States and the Alexander von Humboldt Foundation, Germany (all to V.P.). JA acknowledges the support from the project “Increasing the knowledge intensity of Ida-Viru entrepreneurship” co-funded by the European Union (Grant no. 2021-2027.6.01.23-0034). We also thank a reviewer who provided excellent suggestions that helped to improve the quality of this manuscript.
Supported by: European Union Agency for Cybersecurity Grant no. 2021-2027.6.01.23-0034
Supported by: Alexander von Humboldt Foundation, Germany
Supported by: P. Roy Vagelos chair at the University of Pennsylvania
Abstract
Helical homochirality is available in nature, biology, and, most recently, also in synthetic systems. Selected examples of helical complex systems from nature, biology, and synthetic chemistry will be briefly discussed, most probably for the first time, in a single publication. When available, the mechanisms of the origin of their homochirality will be presented. In order to encourage new discoveries, the historical events of many discoveries will also be highlighted. Potential connections between homochirality in nature and biology, as well as in nature- and bio-inspired macroscopic, molecular, and supramolecular complex systems, will be mentioned.
Keywords
Spiral - Helical - Spherical helix - Homochirality - Self-assembly - Self-organization - Complex systems - Nature- and biological-inspiredPublication History
Received: 05 July 2025
Accepted after revision: 18 August 2025
Accepted Manuscript online:
18 August 2025
Article published online:
27 November 2025
© 2025. Thieme. All rights reserved.
Georg Thieme Verlag KG
Oswald-Hesse-Straße 50, 70469 Stuttgart, Germany
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