Csp³/Csp²–H Functionalized Oxidative [3+2+1] Cyclization for Synthesis of Pyrido[2,3-d]pyrimidines

Abstract

A variety of pyrido[2,3-d]pyrimidines derivatives have been synthesized via Csp³/Csp²–H functionalization of readily available methyl arenes, 6-amino uracil, and malononitrile using K₂S₂O₈ under metal-free and environmentally benign conditions. By using methyl arenes as the C4 source of the pyrido[2,3-d]pyrimidines skeleton, this synthetic strategy provides a series of pyrido[2,3-d]pyrimidines via an oxidative [3+2+1] cyclization process.

Keywords

Pyrido[2,3-d]pyrimidines - C–H functionalization - 6-Amino uracil - Malononitrile - Methylarene

Publikationsverlauf

Eingereicht: 31. Mai 2025

Angenommen nach Revision: 18. August 2025

Accepted Manuscript online:
18. August 2025

Artikel online veröffentlicht:
02. Oktober 2025

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