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Synthesis
DOI: 10.1055/a-2685-8910
Paper

Csp3/Csp2-H functionalized oxidative [3+2+1] cyclization for Synthesis of Pyrido[2,3-d]pyrimidines

Himanshu kumar Singh
1   Chemistry, IIT BHU, Varanasi, India (Ringgold ID: RIN79203)
,
Arsala Kamal
1   Chemistry, IIT BHU, Varanasi, India (Ringgold ID: RIN79203)
,
Ambuj kumar kushwaha
2   Chemistryt, Indian Institute of Technology BHU Varanasi, Varanasi, India (Ringgold ID: RIN79203)
,
Abhishek Jaiswal
3   Chemistry, IITBHU, Varanasi, India (Ringgold ID: RIN79203)
,
Shikha Pandey
3   Chemistry, IITBHU, Varanasi, India (Ringgold ID: RIN79203)
,
Vandana Srivastava
4   Chemistry, Indian Institute of Technology Banaras Hindu University, Varanasi, India (Ringgold ID: RIN79203)
,
sundaram singh
5   chemistry, indian institute of technology(Banaras hindu university), varanasi, India
6   chemistry, I I T B H U, varanasi, India
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A variety of Pyrido[2,3-d]pyrimidines derivatives have been synthesized via Csp3/Csp2-H functionalization of readily available methyl arenes, 6-amino uracil, and malononitrile using K2S2O8 under metal-free and environmentally benign conditions. By using methyl arenes as the C4 source of the Pyrido[2,3-d]pyrimidines skeleton, this synthetic strategy provides a series of Pyrido[2,3-d]pyrimidines via an oxidative [3+2+1] cyclization process.



Publication History

Received: 31 May 2025

Accepted after revision: 18 August 2025

Accepted Manuscript online:
18 August 2025

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