Desaturation of Amides via Bismuth Photocatalysis

Byeongdo Roh; Josep Cornella

doi:10.1055/a-2685-9083

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Synthesis
DOI: 10.1055/a-2685-9083

Paper

Desaturation of Amides via Bismuth Photocatalysis

Byeongdo Roh

¹Organometallic Chemistry, Max-Planck-Institut fur Kohlenforschung, Mulheim an der Ruhr, Germany (Ringgold ID: RIN28314)

,

Josep Cornella

¹Organometallic Chemistry, Max-Planck-Institut fur Kohlenforschung, Mulheim an der Ruhr, Germany (Ringgold ID: RIN28314)

› Author Affiliations
Supported by: Verband der Chemischen Industrie
Supported by: Max-Planck-Gesellschaft
Supported by: Novartis Early Career Award Foundation
Supported by: Deutsche Forschungsgemeinschaft EXC 2033–390677874 –RESOLV
Supported by: Max-Planck-Institut für Kohlenforschung

› Further Information

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Bismuth redox catalysis has been intensively developed in recent years, enabling diverse transformations that were previously thought to be achievable only through transition metal catalysis. In this study, we present the desaturation of amides to generate enamides, an important structural motif in pharmaceuticals, via bismuth photocatalysis. The protocol involves a combination of unique mechanistic steps recently uncovered for bismuth thus allowing for the translation of a canonical transition metal-mediated transformation into a main-group-based catalytic system.

Publication History

Received: 23 June 2025

Accepted after revision: 18 August 2025

Accepted Manuscript online:
18 August 2025

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