Cu(acac)2 catalysed A3-(aldehyde-amine-alkyne) coupling reaction for the synthesis of a wide range of propargylamines and entry to imidazo[1,2-a]pyridines

Cu(acac)2-catalyzed A³-coupling reactions involving an amine, an aldehyde, and a terminal alkyne were explored for the efficient synthesis of a broad range of propargylamines and imidazo[1,2‑a] pyridines. This method demonstrates wide substrate scope and delivers the desired products in good yields under mild reaction conditions. The protocol offers a straightforward and practical approach to access these valuable scaffolds, making it attractive for further synthetic applications.

Publikationsverlauf

Eingereicht: 23. Juni 2025

Angenommen nach Revision: 04. September 2025

Accepted Manuscript online:
04. September 2025