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Synlett
DOI: 10.1055/a-2701-6107
Letter

A Catalyst-Free Transamination of (E)-N,N-Dimethyl Enaminones to β-Amino-α,β-Unsaturated Carbonyl Compounds by Using Isothiocyanates as Amines Proxy

Mahesh Kumar
1   Department of Chemistry, Banaras Hindu University, Varanasi, India
,
Anup Kumar Sharma
1   Department of Chemistry, Banaras Hindu University, Varanasi, India
,
Kaushal Kishor
1   Department of Chemistry, Banaras Hindu University, Varanasi, India
,
Krishna Nand Singh 
1   Department of Chemistry, Banaras Hindu University, Varanasi, India
› Institutsangaben
Gefördert durch: Science and Engineering Research Board CRG/2022/003594
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A facile synthesis of β-amino-α,β-unsaturated carbonyl compounds has been accomplished by the reaction of (E)-N,N-dimethyl enaminones with isothiocyanates under metal, catalyst, base, and additive-free conditions. The reaction is straightforward, and offers transamination with good substrate scope and functional group tolerance. Notably, the aryl isothiocynates serve both as an amine surrogate as well as an activating agent.



Publikationsverlauf

Eingereicht: 25. Juni 2025

Angenommen nach Revision: 14. September 2025

Accepted Manuscript online:
14. September 2025

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