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Synthesis
DOI: 10.1055/a-2705-4229
Paper

Total Synthesis of Vestitol and Medicarpin

Jigang Gao
1   School of Food and Drug, Shenzhen Polytechnic University, Shenzhen, China (Ringgold ID: RIN47891)
2   Chinese Academy of Sciences,, Shenzhen Institutes of Advanced Technology, Shenzen, China
,
Qiling Chen
1   School of Food and Drug, Shenzhen Polytechnic University, Shenzhen, China (Ringgold ID: RIN47891)
,
Shaobin Su
3   Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China (Ringgold ID: RIN12381)
,
Bin Cheng
4   Institute of Marine Biomedicine, Shenzhen Polytechnic University, Shenzhen, China (Ringgold ID: RIN47891)
,
Hongjian Yang
5   Chemistry Department, Foshan Ionova Biotherapeutics Co., Inc, Foshan, China
,
Haiyan Sun
1   School of Food and Drug, Shenzhen Polytechnic University, Shenzhen, China (Ringgold ID: RIN47891)
› Author Affiliations
Supported by: Science, Technology and Innovation Commission of Shenzhen Municipality 20220815100042003
Supported by: Innovation Team of Guangdong Education Department 2022KCXTD054
› Further Information
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Total synthesis of vestitol and medicarpin, two isoflavonoids with distinct skeletons, was successfully achieved using a single intermediate as the starting point. This six-step synthetic approach features a BBr3-promoted tandem O-demethylation/cyclization reaction, which enables the rapid construction of the pterocarpan core structure. Subsequently, a Pd/C-catalyzed hydrogenation/hydrogenolysis reaction was employed to respectively synthesize vestitol and medicarpin.



Publication History

Received: 03 June 2025

Accepted after revision: 29 August 2025

Accepted Manuscript online:
19 September 2025

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