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Synthesis
DOI: 10.1055/a-2722-9900
DOI: 10.1055/a-2722-9900
Paper
Iron-Catalyzed One-Pot Four-Component Synthesis of Dihydropyridinones from Benzyl Alcohols and Ketones
Authors
Abstract
An efficient, facile, and one-pot four-component methodology for the cyclization of readily available benzyl alcohols, acetophenones, Meldrum’s acid, and NH4OAc to access dihydropyridinones (valuable scaffolds in medicinal and synthetic organic chemistry) was established. This four-component cyclization reaction supports the straightforward manufacture of several dihydropyridinones. Several C–C and C–N bonds were constructs to synthesize the desired product. Readily available starting materials, operational simplicity, good to excellent reaction yields, and tolerance of various functional groups are the interesting features of this protocol.
Keywords
Benzyl alcohols - Meldrum’s acid - Dehydrogenation - Knölker catalysts - DihydropyridinonesPublication History
Received: 03 October 2025
Accepted: 14 October 2025
Accepted Manuscript online:
14 October 2025
Article published online:
12 November 2025
© 2025. Thieme. All rights reserved.
Georg Thieme Verlag KG
Oswald-Hesse-Straße 50, 70469 Stuttgart, Germany
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