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CC BY 4.0 · SynOpen
DOI: 10.1055/a-2769-2826
paper

Efficient Dibromination of Aromatics with Fe(NO3)3·9H2O/FeBr3

Authors

  • wenfei yang

    1   school of science, Qiongtai Normal University, Haikou, China (Ringgold ID: RIN224702)

  • Caicui Li

    2   School of Science, Qiongtai Normal University, Haikou, China (Ringgold ID: RIN224702)
    3   Department of Medicinal Chemistry and Natural Medicine Chemistry, Harbin Medical University, Harbin, China (Ringgold ID: RIN34707)

  • Xiaodan Wang

    2   School of Science, Qiongtai Normal University, Haikou, China (Ringgold ID: RIN224702)
    3   Department of Medicinal Chemistry and Natural Medicine Chemistry, Harbin Medical University, Harbin, China (Ringgold ID: RIN34707)

  • Zhengtao Huang

    2   School of Science, Qiongtai Normal University, Haikou, China (Ringgold ID: RIN224702)

  • Xinmei Wang

    1   school of science, Qiongtai Normal University, Haikou, China (Ringgold ID: RIN224702)

  • Yiying Li

    2   School of Science, Qiongtai Normal University, Haikou, China (Ringgold ID: RIN224702)
    4   School of Basic Medicine and Life Sciences, Hainan Medical University, Haikou, China (Ringgold ID: RIN12455)

  • Wubo Wan

    5   Yazhou Bay Innovation Institute, Hainan Tropical Ocean University, Sanya, China (Ringgold ID: RIN47887)

  • Lijuan Wang

    5   Yazhou Bay Innovation Institute, Hainan Tropical Ocean University, Sanya, China (Ringgold ID: RIN47887)

  • Jinhui Wang

    3   Department of Medicinal Chemistry and Natural Medicine Chemistry, Harbin Medical University, Harbin, China (Ringgold ID: RIN34707)

  • huanjun xu

    2   School of Science, Qiongtai Normal University, Haikou, China (Ringgold ID: RIN224702)
    5   Yazhou Bay Innovation Institute, Hainan Tropical Ocean University, Sanya, China (Ringgold ID: RIN47887)

Supported by: National Natural Science Foundation of China 22165009
Supported by: Scientific Research Foundation of the Higher Education Institutions of Hainan Province Hnky2025ZD-16
Supported by: Youth Project of Yazhou Bay Innovation Institute of Hainan Tropical Ocean University 2022CXYQNXM01
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A simple, efficient and environmentally friendly methodology for the dibromination of anisole analogues using Fe(NO3)3•9H2O/FeBr3 at room temperature was developed. In which, most of anisole analogues with electron-donating group and weak electron-withdrawing group could offered the corresponding product in good to excellent yield, while with strong electron-withdrawing group offered a high yield of monbromination product. This protocol was also suitable to the bromination of 2-or 4-substitued substrates. More importantly, this protocol was also applicable for gram-scale synthesis.



Publication History

Received: 04 October 2025

Accepted after revision: 09 December 2025

Accepted Manuscript online:
11 December 2025

© . The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/).

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