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Synthesis 2009(1): 97-104
DOI: 10.1055/s-0028-1083279
DOI: 10.1055/s-0028-1083279
PAPER
© Georg Thieme Verlag
Stuttgart ˙ New York
The Direct Synthesis of Unsymmetrical Vicinal Diamines from Terminal Alkynes: A Tandem Sequential Approach for the Synthesis of Imidazolidinones
Further Information
Received
23 October 2008
Publication Date:
12 December 2008 (online)
Publication History
Publication Date:
12 December 2008 (online)
Abstract
The combination of titanium-catalyzed anti-Markovnikov hydroamination of terminal alkynes with the Strecker reaction is used in the synthesis of unsymmetrical vicinal diamines via the one-pot synthesis of α-cyanoamines. This methodology is further applied to the efficient synthesis of imidazolidinones. An easy-to-use bis(amidate)titanium precatalyst permits efficient approaches to heterocyclic chemistry from terminal alkynes.
Key words
hydroamination - titanium - amines - heterocycles - tandem reactions
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