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Synthesis 2009(4): 561-566
DOI: 10.1055/s-0028-1083336
DOI: 10.1055/s-0028-1083336
PAPER
© Georg Thieme Verlag
Stuttgart ˙ New York
Rapid Synthesis of 3-Aminoisoquinoline-5-sulfonamides Using the Buchwald-Hartwig Reaction
Weitere Informationen
Received
19 August 2008
Publikationsdatum:
27. Januar 2009 (online)
Publikationsverlauf
Publikationsdatum:
27. Januar 2009 (online)
Abstract
A rapid synthesis of previously unreported 3-aminoisoquinoline-5-sulfonamides related to known kinase inhibitors was achieved by a two-step sequential reaction of 3-chloro-5-isoquinolinesulfonyl chloride with amines. Palladium-catalysed C-N bond formation was used to introduce arylamine, alkylamine, and unsubstituted amino groups at C-3 of the isoquinoline.
Key words
palladium catalysis - amination - isoquinolines - sulfonamides
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