Planta Med 2008; 74 - PA10
DOI: 10.1055/s-0028-1084009

Antioxidant properties of some Turkish medicinal plants

II Tatli 1, S Sahpaz 2, F Martin-Nizard 3, A Sezgin 1, O Arısan 1, B Gressier 4, F Bailleul 2, N Ezer 1
  • 1Hacettepe University, Faculty of Pharmacy, Dept. of Pharmaceutical Botany, Sıhhiye, TR-06100 Ankara, Turkey
  • 2Université de Lille 2, Faculté de Pharmacie, Laboratoire de Pharmacognosie (E.A. 1043), B.P. 83, F-59006 Lille, France
  • 3Université de Lille 2, Faculté de Pharmacie B.P. 83, 59006 Lille cedex; Faculté de Médecine, Laboratoire JK, 59035 Lille cedex; INSERM U 545, 59019 Lille cedex; Institut Pasteur de Lille, 59019 Lille cedex, France
  • 4Université de Lille 2, Faculté de Pharmacie, Laboratoire de Pharmacologie et de Pharmacie Clinique, B.P. 83, F-59006 Lille, France

There is a growing interest in oxygen-containing free radicals in biological systems and their implied roles as causative agents in the aetiology of a variety of chronic disorders. The present investigation is a preliminary in ongoing research on plants used in Turkish traditional medicine for their antioxidant activity. These plants mentioned in Table are used for haemorrhoids, abdominal pains and wound healing in traditional Turkish medicine [1,2]. The radical scavenging activities of the methanolic extracts prepared from the aerial parts of these plant species growing in Turkey were evaluated against reactive oxygen species such as superoxide anion (O2·-) and hydrogen peroxide (H2O2) in a non-cellular system as well as versus DPPH radical. Another goal in this study was to test whether methanolic extracts inhibited Cu+2-induced low-density lipoprotein peroxidation. These extracts exhibited dose-dependent inhibition on DPPH radical, as well as Cu+2-induced LDL peroxidation, and the results indicated that all extracts were effective on non-cellular antioxidant systems of O2·- when compared with the H2O2 group. The results are given in Table.

Table. Antioxidant activities of methanolic plant extracts

Plant name

ED50 (mg/L)

DPPH

O2 .-

H2O2

LDL

Hypericum orientale

17.0±1.5

295.1±18.5

309.5±26.9

17.3±2.1

Helichrysium plicatum subsp. plicatum

39.0±4.8

305.2±15.9

301.6±32.6

36.5±4.6

Centaurea drabifolia subsp. detonsa

59.0±5.2

430.6±25.2

583.6±41.9

54.4±5.0

Centaurea drabifolia subsp. drabifolia

80.0±6.1

290.2±15.5

310.5±18.9

71.0±5.8

Achillea wilhelmsii

46.0±4.0

435.2±32.0

>2000

34.2±3.6

Rubus canescens var. canescens

10.0±1.1

283.8±12.0

1740±120

13.1±2.1

References: 1. Ezer, N., Mumcu Arısan, O. (2006) Turk. J. Botany 30: 223–230.

2. Sezgin A (2005) Folk Medicines in Suhut (Afyon), Hacettepe University, Health Sciences Institute, Ms Thesis, Ankara.