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Copper(I)-Catalyzed Hetero-Diels-Alder Reaction of Ketones
I-H. Chen, K. Oisaki, M. Kanai*, M. Shibasaki*
The University of Tokyo, Japan
22 January 2009 (online)
This paper describes the hetero-Diels-Alder reaction between Danishefsky-type dienes and ketones to generate dihydropyranone products, which is a significant extension of the previously developed copper-catalyzed aldol reactions. By using the chiral Walphos ligands, the first catalytic enantioselective hetero-Diels-Alder reaction of simple ketones is realized.