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Highly Active Catalyst for the Addition of Indoles to Nitroalkenes
M. Ganesh, D. Seidel*
The State University of New Jersey, Piscataway, USA
22 January 2009 (online)
Active catalysts for the addition of indoles to nitroalkenes have been developed. Quinolinium thioamide catalyst 1 gave products in high yields and excellent enantioselectivities. Comparison with thiourea-based catalyst 2 reveals a 280-fold effective rate acceleration achieved using catalyst 1, as well as a much higher enantioselectivity.