Synfacts 2009(2): 0207-0207  
DOI: 10.1055/s-0028-1087593
Organo- and Biocatalysis
© Georg Thieme Verlag Stuttgart ˙ New York

Chiral Brønsted Acid-Base Pyridinium Disulfonate Catalysts

Contributor(s): Benjamin List, Frank Lay
M. Hatano, T. Maki, K. Moriyama, M. Arinobe, K. Ishihara*
Nagoya University, Japan
Further Information

Publication History

Publication Date:
22 January 2009 (online)


By combining chiral disulfonic acid 1 and achiral 2,6-diphenylpyridine the authors obtain tailor-made Brønsted acid-base organocatalysts for a direct Mannich-type reaction. Excellent yields and enantioselectivities were achieved with this concept.