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Chiral Brønsted Acid-Base Pyridinium Disulfonate Catalysts
M. Hatano, T. Maki, K. Moriyama, M. Arinobe, K. Ishihara*
Nagoya University, Japan
22 January 2009 (online)
By combining chiral disulfonic acid 1 and achiral 2,6-diphenylpyridine the authors obtain tailor-made Brønsted acid-base organocatalysts for a direct Mannich-type reaction. Excellent yields and enantioselectivities were achieved with this concept.