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Opposite Catalyst Selectivities Using a Common Chiral Source
K. Nakayama, K. Maruoka*
Daiichi Sankyo Co., Kanagawa and Kyoto University, Japan
22 January 2009 (online)
Maruoka and co-worker report an asymmetric aldol reaction of cyclic ketones with substituted benzaldehydes using two different catalysts derived from one source. Switching catalyst 1 to 2 resulted in the formation of the enantiomeric aldol with the opposite absolute configuration. High anti-selectivities and enantioselectivities were obtained employing catalyst 1 or 2.