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Synthesis of Fluvibactin
A. Sakakura, S. Umemura, K. Ishihara*
Nagoya University, Japan
22 January 2009 (online)
Fluvibactin and vibriobactin are siderophores isolated from low-iron cultures of Vibrio fluvialis and Vibrio cholerae. They are Fe(III)-specific chelators that facilitate Fe(III) ion-specific uptake. The synthesis of fluvibactin and vibriobactin (not shown) features the use of a highly efficient Mo(VI)-catalyzed dehydrative cyclization of the N-acyl threonine G to give the oxazoline H.