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Formal Synthesis of Platencin
S. Y. Yun, J.-C. Zheng, D. Lee*
University of Illinois at Chicago, USA
22 January 2009 (online)
Platencin was isolated from a new strain of Streptomyces platensis. It has sparked a great deal of interest due to its novel mode of action and impressive antibiotic properties, especially against drug resistant bacterial strains. This synthesis relies upon a radical cyclization (E → F) to construct the key bicyclic ring system.