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Formal Synthesis of RK-397
H. Guo, M. S. Mortensen, G. A. O’Doherty*
West Virginia University, Morgantown, USA
22 January 2009 (online)
RK-397 is an antibiotic isolated from a Japanese soil bacterium. It showed some antifungal and antibacterial activity along with cytotoxic properties towards certain human leukemia cells (50 mg/mL activity). For a total synthesis of RK-397 see: S. E. Denmark, S. Fujimori J. Am. Chem. Soc. 2005, 127, 8971.