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Synthesis of SCH 351448
L. L. Cheung, S. Marumoto, C. D. Anderson, S. D. Rychnovsky*
University of California, Irvine, USA
22 January 2009 (online)
SCH 351448 is an activator for the LDL receptor promoter isolated from a Micromonospora species. It shows a high Ca²+ binding affinity. Lewis acid induced Prins cyclizations were used to synthesize the tetrahydropyrans in the fragments H, I, J, and K.