Synfacts 2009(2): 0130-0130  
DOI: 10.1055/s-0028-1087612
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of SCH 351448

Contributor(s): Philip Kocienski, Arndt W. Schmidt
L. L. Cheung, S. Marumoto, C. D. Anderson, S. D. Rychnovsky*
University of California, Irvine, USA
Further Information

Publication History

Publication Date:
22 January 2009 (online)


SCH 351448 is an activator for the LDL receptor promoter isolated from a Micro­monospora species. It shows a high Ca²+ binding affinity. Lewis acid induced Prins cyclizations were used to synthesize the tetrahydropyrans in the fragments H, I, J, and K.