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Magnetic Nanoparticles as Inductive Heating Elements in Microreactors
S. Ceylan, C. Friese, C. Lammel, K. Mazac, A. Kirschning*
Leibniz Universität Hannover, Henkel KGaA, Düsseldorf and IFF GmbH, Ismaning, Germany
22 January 2009 (online)
SiO2-coated magnetic nanoparticles 1 and 3 (Fe3O4/Fe2O3 nanoparticles) were developed as heating elements for organic reactions, which were self-heated in an electromagnetic field. Thus, a microflow reactor (14 cm long, ø 9 mm) was filled with a mixture of magnetic nanoparticles 1 and sand (3:1, 5.5 g) without/with 400 mg of Pd-doped material 3 (2.8 mol%, 0.028 mmol Pd). The trans-esterification, Claisen rearrangement, the Buchwald-Hartwig amination, enyne metathesis and Wittig reaction were performed with 1 in an electromagnetic field under continuous-flow conditions to give the corresponding products in 75-98% yield (6 examples).