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Oxygenation of Primary Amines to Amides by Ru(OH)x/Al2O3
J. W. Kim, K. Yamaguchi, N. Mizuno*
The University of Tokyo, Japan
22 January 2009 (online)
The oxygenation of primary amines 2 took place in the presence of Ru(OH)x/Al2O3 catalyst 1 (5 mol% of Ru) in water under air to give the corresponding primary amides 3 in up to 92% yield (11 examples). After the reaction, the catalyst 1 was readily removed from the reaction mixture by simple filtration and reused without significant loss of its catalytic activity (83% yield of isolated benzamide 3a).