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Sequential Heck Coupling and Hydrogenation
M. L. Kantam*, R. Chakravarti, V. R. Chintareddy, B. Sreedhar, S. Bhargava
Indian Institute of Chemical Technology, Hyderabad, India and RMIT University, Melbourne, Australia
22 January 2009 (online)
The nanocrystalline magnesium oxide stabilized palladium (NAPMgPd(0)) promoted the Heck coupling of haloarenes 1 with styrenes 2 and subsequent hydrogenation to give the corresponding dibenzyls 3 (19 examples, 75-98% yield). The catalyst also promoted the sequential reaction of 1 with acrylates 4 to afford the alkyl phenylpropionates 5 (8 examples, 78-90% yield).