Synfacts 2009(2): 0203-0203  
DOI: 10.1055/s-0028-1087649
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Hiyama Cross-Coupling of Aryl Mesylates

Contributor(s): Paul Knochel, Andrei Gavryushin
L. Zhang, J. Qing, P. Yang*, J. Wu*
Fudan University, Shanghai and Shanghai Institute of Organic Chemistry, P. R. of China
Further Information

Publication History

Publication Date:
22 January 2009 (online)


Aryl mesylates can be easily prepared from the corresponding phenols and have the advantage of a higher atom economy in cross-coupling reactions. On the other hand, the Hiyama coupling offers an advantage of the environmentally benign wastes, and excellent functional group tolerance. This is the first publication of the use of aryl mesylates in the Hiyama cross-coupling reaction. While using a relatively expensive ligand and palladium as a catalyst, this work gives useful insights for the better understanding of the important C-C bond-formation processes.