Synfacts 2009(2): 0194-0194  
DOI: 10.1055/s-0028-1087650
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Ni-Catalyzed Reductive Carboxylation of Styrenes Using CO2

Contributor(s): Paul Knochel, Andrei Gavryushin
C. M. Williams, J. B. Johnson, T. Rovis*
Colorado State University, Fort Collins, USA
Further Information

Publication History

Publication Date:
22 January 2009 (online)


CO2 is an attractive C1 synthon. Transition-metal catalysis for the incorporation of CO2 into organic molecules remains, however, mostly unexplored. The reductive carboxylation of styrenes may serve as a useful method for the preparation of arylpropionic acids. Besides, it provides a basis for the preparation of more complex synthetic targets. This process has excellent versatility and functional group compatibility. It is ­operationally very simple and utilizes CO2 at a ­normal pressure and temperature, avoiding the need in special equipment.