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Ni-Catalyzed Reductive Carboxylation of Styrenes Using CO2
C. M. Williams, J. B. Johnson, T. Rovis*
Colorado State University, Fort Collins, USA
22 January 2009 (online)
CO2 is an attractive C1 synthon. Transition-metal catalysis for the incorporation of CO2 into organic molecules remains, however, mostly unexplored. The reductive carboxylation of styrenes may serve as a useful method for the preparation of arylpropionic acids. Besides, it provides a basis for the preparation of more complex synthetic targets. This process has excellent versatility and functional group compatibility. It is operationally very simple and utilizes CO2 at a normal pressure and temperature, avoiding the need in special equipment.