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Addition of LiCH2I to Imines: An Efficient Synthesis of Aziridines
H. Rodríguez-Solla, C. Simal
Universidad de Oviedo, Spain
22 January 2009 (online)
A simple and rapid experimental protocol for the synthesis of aziridines from aldimines is reported for the first time. The use of a chiral aldimine yielded the corresponding chiral aziridine with very high diastereoselectivity and excellent enantiomeric excess.