Synfacts 2009(2): 0196-0196  
DOI: 10.1055/s-0028-1087653
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Addition of LiCH2I to Imines: An Efficient Synthesis of Aziridines

Contributor(s): Paul Knochel, Andreas J. Wagner
H. Rodríguez-Solla, C. Simal
Universidad de Oviedo, Spain
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Publication History

Publication Date:
22 January 2009 (online)


A simple and rapid experimental protocol for the synthesis of aziridines from ­aldimines is reported for the first time. The use of a chiral aldimine yielded the corresponding chiral aziridine with very high diastereoselectivity and ­excellent enantiomeric excess.