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Synfacts 2009(2): 0189-0189
DOI: 10.1055/s-0028-1087658
DOI: 10.1055/s-0028-1087658
Metal-Mediated Synthesis
© Georg Thieme Verlag
Stuttgart ˙ New York
Mn-Catalyzed Cross-Coupling of Aryl Grignard Reagents with Alkenyl Halides
G. Cahiez*, O. Gager, F. Lecomte
Université de Paris13, Bobigny, France
Further Information
Publication History
Publication Date:
22 January 2009 (online)
Significance
In this article a highly stereoselective Mn(II)-catalyzed cross-coupling reaction between (hetero)aryl Grignard reagents and non-activated alkenyl halides is reported. The stereoinformation of the alkenyl halide is usually preserved. An exception to that rule represents the case of (Z)-3-(2-bromoethenyl)pyridine, where the configuration of the double bond is completely reversed.