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Planta Med 1979; 35(3): 235-241
DOI: 10.1055/s-0028-1097210
Research Articles

© Georg Thieme Verlag Stuttgart · New York

Cytotoxic Activity of 6,20–Epoxylathyrol and its Aliphatic Diesters

G. Schroeder1 , M. Rohmer1 , J. P. Beck2 , R. Anton1
  • 1Laboratoire de Pharmacognosie, Faculté de Pharmacie, Strasbourg, France.
  • 2Institut de Physiologie et de Chimie Biologique, Strasbourg, France.
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Publication History

Publication Date:
13 January 2009 (online)

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Abstract

6,20–epoxylathyrol, isolated from Euphorbia lathyris L., is a pharmacologically inactive lathyrane type diterpene. After alkaline hydrolysis and reesterification of this natural product with aliphatic acids of various chain lengths, some 3,5–aliphatic diesters showed interesting cytotoxic properties. The influence of liposolubility on cytotoxic activity of 6,20–epoxylathyrol diesters is discussed.

Key Word Index

Euphorbia lathyris L - Diterpene - 6,20–Epoxylathyrol - Cytotoxicity - HTC Hepatoma Cells

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