Planta Med 1979; 36(5): 87-90
DOI: 10.1055/s-0028-1097246
Research Articles

© Georg Thieme Verlag Stuttgart · New York

A Bioassay of Antimitotic Alkaloids of Catharanthus roseus

M. M. El–Merzabani, A. A. El–Aaser, A. K. El–Duweini1 , A. M. El–Masry2
  • The Cancer Institute, Cairo University.
1 Academy of Scientific Research and Technology, Egypt. 2 Department of Pharmacology and Biochemistry, Faculty of Pharmacy, Cairo University.
Further Information

Publication History

Publication Date:
13 January 2009 (online)


This paper describes a bioassay for the quantitative determination of the antimitotic principle(s) present in the periwinkle plant using mice bearing Ehrlich ascites carcinoma (EAC). The method proved accurate, specific, simple and cheap. It could be of great value for the phytochemical screening of plants intended to discover new active compounds capable of arresting mitosis of tumor cells in the metaphase.