Download PDF
Planta Med 1979; 37(10): 115-123
DOI: 10.1055/s-0028-1097310
Research Articles

© Georg Thieme Verlag Stuttgart · New York

Pharmakologische Untersuchungen von Kamillen–Inhaltsstoffen – IV. Untersuchungen zur Toxizität des (–)–α–Bisabolols.*

Pharmacological Studies with Compounds of Chamomile – IV. Studies on Toxicity of (–)–α–BisabololS. Habersang, F. Leuschner, O. Isaac, K. Thiemer
  • Aus der Pharma–Forschung und der Anwendungstechnik Naturstoffe, Chemiewerk Homburg, Zweigniederlassung der Degussa, Frankfurt am Main, und dem Laboratorium für Pharmakologie und Toxikologie, Hamburg, Bundesrepublik Deutschland.
* III. Mitteilung: Planta Med. 35, 218 (1979)
Further Information

Publication History

Publication Date:
13 January 2009 (online)

Also available at
  PDF Download  Permissions and Reprints

See also:

Pharmakologische Untersuchungen von Kamillen–Inhaltsstoffen – III. Tierexperimentelle Untersuchungen über die ulkusprotektive Wirkung der KamillePlanta Med 1979; 35(03): 218-227
DOI: 10.1055/s-0028-1097208

Abstract

The acute toxicity of (–)–α–bisabolol, a main active principle of chamomile, Matricaria chamomilla L., is very low in mice and rats after oral administration. For dogs and rhesus monkeys the oral compatibility is good as well. Side effects occur at high dosages only.

In the four weeks' subacute toxicity studies the toxicity threshold in rats and dogs ranges between 1.0 and 2.0 ml of bisabolol/kg body weight after oral administration.

Influence upon the prenatal development of rats and white New Zealand rabbits cannot be detected after peroral administration of up to 1.0 ml of bisabolol/kg body weight. Incompatibility reactions occur only in the dosage range already toxic to the dam. No teratogenic effect was observed at any dosage tested.

Key Word Index

Matricaria chamomilla - Compositae - (–)–α–Bisabolol - Toxicity