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Planta Med 1979; 37(11): 274-276
DOI: 10.1055/s-0028-1097340
Research Articles

© Georg Thieme Verlag Stuttgart · New York

Local Anaesthetic Action of the Chinese Medicine „Saiko–Keishi–To”

A. Sugaya1 , T. Tsuda1 , E. Sugaya2 , M. Usami3 , K. Takamura3
  • 1Faculty of Pharmaceutical Sciences, Josai University, Keyakidai, Sakado, Saitama, Japan.
  • 2Department of Physiology, Kanagawa Dental College, Yokosuka, Japan.
  • 3Research Laboratory, Chugai Pharmaceutical Co. Ltd., Tokyo, Japan.
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Publication History

Publication Date:
13 January 2009 (online)

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Abstract

The local anaesthetic action of the Chinese herbal medicine „Saiko–Keishi–To” (SK) and its component crude drugs was examined using the sciatic nerve of the frog. The local anaesthetic action of the 2 % solution of SK extract was 0.29 ± 0.08 times that of 0.5 % procaine solution, and 2 % solutions of extracts of Bupleuri Radix, Cinnamomi Cortex and Zingiberis Rhizoma showed 1.65 + 0.22, 1.66 + 0.13 and 0.73 + 0.20 times the 0.5 % procaine effect respectively.

Key Word Index

Bupleuri Radix - Cinnamomi Cortex - Zingiberis Rhizoma - Sciatic Nerve - Bufo vulgaris - Local Anaesthetic Action

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