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Planta Med 1977; 31(1): 1-7
DOI: 10.1055/s-0028-1097479
© Georg Thieme Verlag Stuttgart · New York

BIOTRANSFORMATION VON CARDENOLIDEN DURCH ZELLSUSPENSIONSKULTUREN VON DIGITALIS LANATA UND THEVETIA NERIIFOLIA1

Biotransformation of Cardenolides by Cell Suspension Cultures of Digitalis lanata and Thevetia neriifoliaP. C. Döller, A. W. Alfermann, E. Reinhard
  • Lehrstuhl für Pharmazeutische Biologie der Universität Tübingen
1 Mit Unterstützung des Bundesministeriurns für Forschung und Technologie.
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Publication History

Publication Date:
13 January 2009 (online)

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Abstract

Cell cultures of Digitalis lanata and of Thevetia neriifolia were incubated with different cardenolides. Cymarin was glucosylated to k-strophanthin by Thevetia cell cultures, peruvosid to a diglycoside. Administered thevetin A and B, respectively, were deglucosylated to peruvosid and neriifolin. Lanatoside A was desacetylated and deglucosylated to digitoxin. Cell cultures of Digitalis glucosylated peruvosid to the diglycoside and deglucosylated thevetin A and B. Thevetia as well as Digitalis cell cultures were able to reduce C–19 of peruvosid to neriifolin.

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