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Planta Med 1977; 31(4): 351-356
DOI: 10.1055/s-0028-1097543
© Georg Thieme Verlag Stuttgart · New York

CYTOSTATIC ACTIVITY OF SOME CANARY ISLANDS SPECIES OF RUTACEAE

A. G. Gonzalez, V. Darias, G. Alonso, J. N. Boada, F. Rodriguez–Luis
  • Instituto de Producto Naturales Orgánicos del C.S.I.C. La Laguna. Tetierife (Canary Islands), Instituta de Quimica Médica del C.S.I.C. Madrid, Spain
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Publication Date:
13 January 2009 (online)

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Abstract

Eighteen coumarins from different species of Ruta collected in the Canary Islands were tested for cytostatic activity. Rutamarin proved to be strikingly cytotoxic.

We tried to establish the structure/activity relationship and also to elucidate the mechanism of the activity of this constituent.