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Planta Med 1977; 32(7): 287-296
DOI: 10.1055/s-0028-1097603
© Georg Thieme Verlag Stuttgart · New York

ÜBER DAS SENSIBILISIERUNGSVERMÖGEN NATÜRLICH VORKOMMENDER CHINONE*

3. Mitt. Ein neues Kontaktallergen (2–Dimethylallyl–1,4–benzochinon) aus Phagnalon sp. (Compositae) On the sensitizing capacity of naturally occurring quinonesPart III. A new contact allergen (2–dimethylallyl–1,4–benzoquinone) from Phagnalon sp. (Compositae)B. M. Hausen, K. H. Schulz
  • Universitäts–Hautklinik Hamburg–Eppendorf
* 1. Mitt. Arch. Derm. Res. 258, 41 (1977) (Naphthoquinones) 2. Mitt. Arch. Derm. Res. im Druck (Benzoquinones)
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Publication Date:
13 January 2009 (online)

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Abstract

With 2–dimethylallyl–1,4–benzoquinone derived from the widespread plant Phagnalon saxatile (L.) Cass. of the mediterranean area guinea pigs could be sensitized by the open epicutaneous method. Thus, this simple benzoquinone has to be considered as a middlestrong sensitizer.

Eliciting of allergic cross reactions in the sensitized guinea pigs could be achieved with 4 out of 12 different quinones (primin, deoxylapachol, thymoquinone and mansoniaquinone). The relationship between chemical structure and sensitizing capicity of these quinoid compounds is discussed.

In different parts of the related species Phagnalon rupestre (L.) DC, P. sordidum (L.) Rechb. and P. atlanticum Ball, the quinone could be detected too by thin layer chromatography.

From the fruits, leaves and stems of P. sordidum 0,02 % of 2–dimethylallyl-p-benzoquinone could be isolated.

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