Henrylactones A–E and Anti-HBV Constituents from Illicium henryi

Abstract

Five new sesquiterpene lactones, henrylactones A–E (1–5), together with ten known compounds: cycloparvifloralone (6), tashironin (7), tashironin A (8), neoanisatin (9), anisatin (10), anislactone B (11), 7-O-acetylanislactone B (12), merrillianolide (13), cyclomerrillianolide (14) and pseudomajucin (15), were isolated from the stems and roots of Illicium henryi. Their structures were elucidated based on extensive spectroscopic data analyses. Among them, henrylactone A (1) is a novel sesquiterpene with a dilactone moiety and its structure was confirmed by X‐ray diffraction. Sesquiterpene lactones 1–15 were tested for their anti-hepatitis B virus (HBV) activities. The most active compound, tashironin (7), exhibited an IC₅₀ value of 0.48 mM (SI = 6.3) inhibiting on HBV surface antigen (HBsAg) secretion and an IC₅₀ value of 0.15 mM (SI = 20.1) inhibiting on HBV e antigen (HBeAg) secretion using HBV transfected Hep G2.2.15 cell line.

Key words

Illiciaceae - Illicium henryi - sesquiterpene lactone - henrylactones A–E - anti‐HBV activity

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