α-Glucosidase Inhibitory, Aromatase Inhibitory, and Antiplasmodial Activities of a Biflavonoid GB1 from Garcinia kola Stem Bark

Abstract

The biflavonoid, 3′′,4′,4′′′,5,5′′,7,7′′-heptahydroxy-3,8-biflavanone, known as GB1 (1), was isolated as a major constituent from Garcinia kola stem bark. GB1 (1) exhibited α-glucosidase and aromatase inhibitory activities, as well as antiplasmodial activity, but was not toxic against cell lines tested. GB1 (1) may be a potential dietary supplement or phytomedicine for the prevention of breast cancer and type 2 diabetes mellitus.

Key words

Garcinia kola - Guttiferae - α‐glucosidase inhibitor - aromatase inhibitor - antiplasmodial - biflavonoid

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