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Synthesis 2009(23): 3963-3966  
DOI: 10.1055/s-0029-1217053
PAPER
© Georg Thieme Verlag Stuttgart ˙ New York

Simple and Efficient Access to 3-Ethoxycarbonylpyrroles, Benzofurans, and Naphthofurans

Camila G. Pancotea, Bruno S. de Carvalhob, Cibele V. Luchezb, João P. S. Fernandesa, Mario J. Politib, Carlos A. Brandt*c
a Departamento de Farmácia, Faculdade de Ciências Farmacêuticas, Universidade de São Paulo, 05508-900 São Paulo, SP, Brazil
b Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, 05508-900 São Paulo, SP, Brazil
c Instituto Butantan,, Av. Vital Brazil 1500, 05503-900 São Paulo, SP, Brazil
e-Mail: cabrandt@usp.br;
Further Information

Publication History

Received 29 April 2009
Publication Date:
19 October 2009 (online)

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Abstract

An efficient method was developed for the synthesis of pyrrole and furan derivatives from enamines, phenols, and naphthols. The key steps involve iodocyclization and alumina-induced dehydroiodination reactions.

Key words

alumina - dehydroiodination - heterocycles - iodocyclization - ultrasound

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