Stereoselective Synthesis of Novel Isonucleoside Analogues of Purine with a Tetrahydropyran Ring

Abstract

New tetrahydropyran isonucleoside derivatives of purine, with cis or trans configuration, were stereoselectively synthesized in moderate yield by a convergent strategy based on Mitsunobu coupling. The key starting material was a bicyclic lactone.

Key words

isonucleosides - heterocycles - tetrahydropyran - purine - Mitsunobu reaction

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