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Synthesis of (-)-Quinocarcin
K. M. Allan, B. M. Stoltz*
California Institute of Technology, Pasadena, USA
22 June 2009 (online)
Quinocarcin (and its derivatives) have antiproliferative activity against lymphocytic leukemia, non-small cell lung cancer and adenocarcinoma. The key step is the annulation of the aryne derived from silyl aryltriflate G with N-acyl enamine F to give the isoquinoline H.