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Synthesis 2010(12): 2011-2016  
DOI: 10.1055/s-0029-1220012
PAPER
© Georg Thieme Verlag Stuttgart ˙ New York

Efficient Syntheses of Naphthoquinone-Dipeptides

Alan R. Katritzky*, Longchuan Huang, Rajeev Sakhuja
Center for Heterocyclic Compounds, Department of Chemistry, University of Florida, Gainesville, FL 32611-7200, USA
Fax: +1(352)3929199; e-Mail: katritzky@chem.ufl.edu;
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Publication History

Received 22 December 2009
Publication Date:
25 May 2010 (online)

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Abstract

Naphthoquinone-dipeptides are synthesized in 76-89% yield from naphthoquinone-amino acid conjugates by N-acylbenzotriazole methodology in aqueous media at 20 ˚C.

Key words

quinones - amino acids - peptides - coupling - conjugation

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