Minor Secondary Metabolic Products from the Stem Bark of Plumeria rubra Linn. Displaying Antimicrobial Activities

Abstract

Four new iridoids viz., plumeridoids A (1), B (2), and C (3) and epiplumeridoid C (4) were isolated from the stem bark of Plumeria rubra Linn. together with twenty-four known compounds viz., 1-(p-hydroxyphenyl)propan-1-one, isoplumericin, plumericin, dihydroplumericin, allamcin, fulvoplumerin, allamandin, plumieride, p-E-coumaric acid, 2,6-dimethoxy-p-benzoquinone, scopoletin, cycloart-25-en-3β,24-diol, 2,4,6-trimethoxyaniline, ajunolic acid, ursolic acid, oleanolic acid, β-amyrin acetate, betulinic acid, lupeol and its acetate, 2,3-dihydroxypropyl octacosanoate, glucoside of β-sitosterol, and a mixture of common sterols (stigmasterol and β-sitosterol). Their structures were determined by means of spectroscopic data including HREIMS, ¹H NMR, ¹³C NMR, 2D NMR (HMQC, HMBC, NOESY) and by comparison with published data. All but one of thirteen tested compounds exhibited antifungal, antialgal, and/or antibacterial activities.

Key words

Plumeria rubra - Apocynaceae - iridoids - plumeridoids A–C - antimicrobial activity

References

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