Planta Med 2010; 76(7): 719-721
DOI: 10.1055/s-0029-1240674
Natural Product Chemistry
Letters
© Georg Thieme Verlag KG Stuttgart · New York

6-Methoxypodophyllotoxin-7-O-n-Hexanoate, a New Aryltetralin Lignan Ester from Seeds of Linum flavum

Michael Klaes1 , Therese Ellendorff1 , Thomas J. Schmidt1
  • 1Institut für Pharmazeutische Biologie und Phytochemie, Westfälische Wilhelms-Universität Münster, Münster, Germany
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Publikationsverlauf

received September 7, 2009 revised November 2, 2009

accepted November 5, 2009

Publikationsdatum:
03. Dezember 2009 (online)

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Abstract

A new aryltetralin-type lignan, 6-methoxypodophyllotoxin-7-O-n-hexanoate, was isolated from the seeds of Linum flavum L. var. compactum (Linaceae) by silica gel column chromatography of the dichloromethane extract. This lignan, previously detected by our group in the aerial parts of several Linum species by HPLC‐MS, has now been isolated for the first time, and its structure is now confirmed and fully characterized by assignment of all NMR data as well as the CD spectrum. The occurrence of aryltetralin lignans, which are well known in the case of aerial parts and roots, in the seeds of a Linum species has not been reported before.

References

Prof. Dr. Thomas J. Schmidt

Institut für Pharmazeutische Biologie und Phytochemie
Westfälische Wilhelms-Universität Münster

Hittorfstraße 56

48149 Münster

Germany

Telefon: + 49 25 18 33 33 78

Fax: + 49 25 18 33 83 41

eMail: thomschm@uni-muenster.de