Planta Med 2010; 76(9): 858-862
DOI: 10.1055/s-0029-1240816
Pharmacology
Original Papers
© Georg Thieme Verlag KG Stuttgart · New York

Lapachol Induces Clastogenic Effects in Rats

Edson Luis Maistro1 , Diego Mota Fernandes1 , Fernanda Maria Vieira Pereira1 , Sergio Faloni Andrade2
  • 1Departamento de Fonoaudiologia, Faculdade de Filosofia e Ciências, Universidade Estadual Paulista (UNESP), Marília, São Paulo, Brazil
  • 2Programa de Mestrado em Ciências Farmacêuticas, Núcleo de Investigações Químico-Farmacêuticas (NIQFAR), Universidade do Vale do Itajaí – UNIVALI, Itajaí, Santa Catarina, Brazil
Further Information

Publication History

received October 9, 2009 revised Dec. 15, 2009

accepted Dec. 24, 2009

Publication Date:
28 January 2010 (online)

Abstract

Lapachol is a naturally occurring naphthoquinone derivative found in the heartwood of several plants, particularly those of the genus Tabebuia (Bignoneaceae). Despite its use as a therapeutic product with anti-inflammatory, analgesic, antipsoriatic, trypanocidal effects, among others, its in vivo mutagenic potential has still not been investigated. This paper reports the effects after a single oral administration of lapachol in the in vivo micronucleus (MN) and chromosome aberration (CA) assays. Both assays were performed using bone marrow cells from male Wistar rats. The animals were treated by oral gavage with hydroalcoholic solutions of lapachol at the doses of 122, 244 and 365 mg/kg, chosen on the basis of the LD50 in male rats. The results show that the higher administered lapachol dose induced a significant increase in the frequency of micronucleated polychromatic erythrocytes (MNPCE) and CAs in rat bone marrow cells, indicating that lapachol shows clastogenic effects under the experimental conditions used.

References

Dr. Edson Luis Maistro

Departamento de Fonoaudiologia
Faculdade de Filosofia e Ciências
Universidade Estadual Paulista – UNESP

Av. Hygino Muzzi Filho 737

Caixa Postal 181

Marília, SP 17525–900

Brazil

Phone: + 55 14 34 02 13 24

Fax: + 55 14 34 02 13 02

Email: edson.maistro@marilia.unesp.br