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DOI: 10.1055/s-0030-1250030
© Georg Thieme Verlag KG Stuttgart · New York
In Vitro Anti-influenza Viral Activities of Stilbenoids from the Lianas of Gnetum pendulum
Publication History
received March 6, 2010
revised April 7, 2010
accepted May 9, 2010
Publication Date:
10 June 2010 (online)
Abstract
The anti-influenza viral activities of six stilbenoids from the lianas of Gnetum pendulum C. Y. Cheng were evaluated with two different assays, neuraminidase (NA) activity assay and cytopathic effect (CPE) reduction assay. The NA assay results showed that all six stilbenoids exerted an NA inhibitory effect, while the CPE assay indicated that among them, isorhapontigenin (2), gnetupendin B (3), shegansu B (4), and gnetin D (6) exhibit significant in vitro anti-influenza viral activity in MDCK cells, with IC50 values from 0.67 to 11.99 µg/mL in comparison to the positive controls oseltamivir acid and ribavirin whose IC50 values were 0.040 and 5.54 µg/mL, respectively.
Key words
Gnetum pendulum - Gnetaceae - influenza virus - neuraminidase - stilbenoid
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Dr. Simon Ming-Yuen Lee
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Prof. Dr. Guan-Hua Du
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