Antitubercular Resorcinol Analogs and Benzenoid C-Glucoside from the Roots of Ardisia cornudentata

Abstract

Bioassay-guided fractionation of the roots of Ardisia cornudentata Mez (Myrsinaceae) led to the isolation of three new compounds, 3-methoxy-2-methyl-5-pentylphenol (1), 3-methoxy-2-methyl-5-(1′-ketopentyl)phenol (2), and cornudoside (3), together with twenty-six known compounds. Their structures were elucidated by analysis of spectroscopic data. Thirteen of these isolates, 1, 2, 4–6, 9–15, and 21 showed antitubercular activities against Mycobacterium tuberculosis H37R_V in vitro, with MIC values of 2.5–60 µg/mL. Two alkyl benzoquinones, ardisianone (7) and cornudentanone (8), were reported for their selective cytotoxic activity against the NCI-H460 cancer cell line (IC₅₀ values of 2.3, 2.5 µg/mL).

Key words

Ardisia cornudentata - Myrsinaceae - resorcinol - benzenoid C‐glucoside - antitubercular activities - cytotoxicity

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