Planta Med 2011; 77(4): 380-382
DOI: 10.1055/s-0030-1250369
Natural Product Chemistry
Letters
© Georg Thieme Verlag KG Stuttgart · New York

New Guaiane Sesquiterpene Lactones from Ixeris dentata

Mi-Ran Cha1 , 2 , Yeon Hee Choi1 , Chun Whan Choi1 , 2 , Dae Seok Yoo1 , 2 , Young Sup Kim1 , Sang Un Choi1 , Young Ho Kim2 , Shi Yong Ryu1
  • 1Korea Research Institute of Chemical Technology, Daejeon, Korea
  • 2College of Pharmacy, Chungnam National University, Daejeon, Korea
Further Information

Publication History

received July 1, 2010 revised August 10, 2010

accepted August 25, 2010

Publication Date:
01 October 2010 (online)

Abstract

Three new guaiane-type sesquiterpene lactones (13), together with nine related sesquiterpenes (412), were isolated from the whole extract of Ixeris dentata (Asteraceae). The chemical structures of isolates 112 were established by spectroscopic analyses as 3β,8β-dihydroxy-guaia-10(14)-en-1α,4α,5α,6β,7α,11βH‐12,6α-olide (1), ixerin N 6′-O-acetate (2), ixerisoside A 6′-O-acetate (3), ixerin N (4), ixerisoside A (5), ixerin M (6), tectroside (7), 8-epidesacylcynaropicrin glucoside (8), 8-epiisolipidiol (9), 11βH‐11,13-dihydrointegrifolin (10) 8β-hydroxy-4β,15-dihydrozaluzanin C (11), and integrifolin (12). Compounds 112 were evaluated for their inhibitory effect on the proliferation of the cultured human tumor cell lines MES‐SA, MES‐SA/DX5, HCT-15, and HCT15/CL02 in vitro.

References

Dr. Shi Yong Ryu

Korea Research Institute of Chemical Technology

Yusung P. O. Box 107

Daejeon 305-343

Korea

Phone: +82 4 28 60 71 63

Fax: +82 4 28 61 03 07

Email: syryu@krict.re.kr