Planta Med 2011; 77(4): 374-376
DOI: 10.1055/s-0030-1250370
Natural Product Chemistry
Letters
© Georg Thieme Verlag KG Stuttgart · New York

In Vitro BACE-1 Inhibitory Activity of Resveratrol Oligomers from the Seed Extract of Paeonia lactiflora

Chun Whan Choi1 , 2 , Yeon Hee Choi1 , Mi-Ran Cha1 , 2 , Young Sup Kim1 , Gyu Hwan Yon2 , Kyung Sik Hong1 , Woo-Kyu Park2 , Young Ho Kim2 , Shi Yong Ryu1
  • 1Korea Research Institute of Chemical Technology, Daejeon, Korea
  • 2College of Pharmacy Chungnam National University, Daejeon, Korea
Further Information

Publication History

received July 15, 2010 revised August 24, 2010

accepted August 26, 2010

Publication Date:
01 October 2010 (online)

Abstract

A new resveratrol oligomer (1) together with eight related components (29) were isolated from the seed extract of Paeonia lactiflora (Paeoniaceae) as active principles responsible for the inhibition of beta-site APP-cleaving enzyme 1 (BACE-1) in vitro. The chemical structure of 1 was established as (−)-7a,8a-cis-ε-viniferin with the aid of spectroscopic analyses including NOESY experiments. All isolated resveratrol oligomers (19) demonstrated significant inhibition on baculovirus-expressed BACE-1 in a dose-dependent manner, which was assessed by the FRET assay using Rh-EVNLDAEFK as a substrate in vitro.

References

Dr. Shi Yong Ryu

Korea Research Institute of Chemical Technology

Yusung P. O. Box 107

Daejeon 305-606

Korea

Phone: +82 4 28 60 71 63

Fax: +82 04 28 61 03 07

Email: syryu@krict.re.kr