Planta Med 2011; 77(4): 377-379
DOI: 10.1055/s-0030-1250384
Natural Product Chemistry
Letters
© Georg Thieme Verlag KG Stuttgart · New York

Antiplasmodial Constituents from the Fruit Pericarp of Pentadesma butyracea

Bruno Ndjakou Lenta1 , Louis Marie Kamdem2 , Silvère Ngouela2 , Ferdinand Tantangmo2 , Krishna Prasad Devkota3 , Fabrice Fekam Boyom4 , Philip John Rosenthal5 , Etienne Tsamo2
  • 1Department of Chemistry, Higher Teachers' Training College, University of Yaoundé 1, Yaoundé, Cameroon
  • 2Department of Organic Chemistry, Faculty of Science, TWAS Research Unit, University of Yaoundé 1, Yaoundé, Cameroon
  • 3Department of Chemistry, Organic and Bioorganic Chemistry, Bielefeld University, Bielefeld, Germany
  • 4Department of Biochemistry, University of Yaoundé 1, Faculty of Science, Yaoundé, Cameroon
  • 5Division of Infectious Diseases, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA
Further Information

Publication History

received March 22, 2010 revised September 1, 2010

accepted September 3, 2010

Publication Date:
06 October 2010 (online)

Abstract

Bioassay-guided fractionation of the fruit pericarp of Pentadesma butyracea, using the antiplasmodial test, led to the isolation of a new xanthone, named pentadexanthone (1), together with six known compounds: cratoxylone (2), α-mangostin (3), 1,3,5-trihydroxy-2-methoxyxanthone (4), garcinone E (5), (−)-epicathechin (6), and lupeol (7). The structure of 1 was elucidated by spectroscopic data analysis. An antiplasmodial assay was performed with the isolates, in which compounds 13 and 5 exhibited potent activity in vitro against Plasmodium falciparum chloroquine-resistant strain W2, with IC50 values below 3 µM.

References

Dr. Bruno Ndjakou Lenta

Department of Chemistry
Higher Teachers' Training College
University of Yaoundé 1

P. O. Box 47

237 Yaoundé

Cameroon

Phone: +23 7 75 09 75 61

Email: lentabruno@yahoo.fr