Planta Med 2011; 77(4): 383-387
DOI: 10.1055/s-0030-1250401
Natural Product Chemistry
© Georg Thieme Verlag KG Stuttgart · New York

Cytotoxic Aporphine Alkaloids from Ocotea acutifolia

Fernanda R. Garcez1 , Ana G. Francisca da Silva1 , 3 , Walmir S. Garcez1 , Gabriela Linck2 , Maria C. de Fatima Matos2 , Evelyn C. S. Santos2 , Lyara M. M. Queiroz2
  • 1Departamento de Química, Universidade Federal de Mato Grosso do Sul, Campo Grande, MS, Brazil
  • 2Departamento de Farmácia-Bioquímica, Universidade Federal de Mato Grosso do Sul, Campo Grande, MS, Brazil
  • 3Universidade Estadual de Mato Grosso do Sul, Mundo Novo, MS, Brazil
Further Information

Publication History

received February 18, 2010 revised August 6, 2010

accepted September 10, 2010

Publication Date:
04 October 2010 (online)


Two new aporphinoid alkaloids, (+)-6S-ocoteine N-oxide and (+)-norocoxylonine, were isolated from the leaves and trunk bark of Ocotea acutifolia (Lauraceae) along with thirteen aporphine analogues, one morphinan alkaloid, and one flavonoid. The aporphine alkaloids (+)-thalicsimidine and (+)-neolitsine are reported for the first time for the genus Ocotea. The structures of all compounds were established on the basis of 1D- and 2D‐NMR spectroscopic techniques, optical rotation and/or mass spectrometry data. The cytotoxic potential of eight of the aporphine alkaloids against four human cancer cell lines (Hep-2, MCF-7, B16-F10 and 786-0) was also evaluated.


Dr. Fernanda Rodrigues Garcez

CCET, Departamento de Química
Universidade Federal de Mato Grosso do Sul

Cidade Universitária

Campo Grande, MS 79074-460


Phone: +55 67 33 45 35 79

Fax: +55 67 33 45 35 52